Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity
نویسندگان
چکیده
منابع مشابه
The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport
2-hydroxyoleic acid (OHOA, Minerval®) is an example of a substance used for membrane lipid therapy, where the cellular membranes rather than specific proteins constitute the therapeutical target. OHOA is thought to mediate its anti-tumor effect by affecting the biophysical properties of membranes, which leads to altered recruitment and activation of amphitropic proteins, altered cellular signal...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2019
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20181661